Synthesis of Sulpha Drug Quinazolin -4-one Derivatives and Their Evaluation for Anti-inflammatory Activity

A rapid preparation of compounds 1-31, with the objective of discovering novel and potent antiinflammatory agent. All the compounds exhibited anti-inflammatory and analgesic activities at the dose 50 mg/kg p.o.The compound 6-bromo -2-((2-(2-chlorophenyl)-4-oxothiazolidin-1-yl-amino) methyl)–N-(pyrimidin-2ylbenzenesulfonamide) quinazolin-4(3H)-one 29 showed better anti-inflammatory and analgesic activities at the three graded dose of 25, 50 and 100 mg/kg p.o.. The structure of all the synthesized compounds were elucidated by spectral (IR, HNMR ) and elemental (C, H, N) analysis. 1